Sodium Hydroxide → 1-{4-[5-(2-Fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4,4-dicarboxylic acid benzyl ester

HRID 2407505노트

반응식

HRID 2407505 반응식
[OH-].[Na+].[CH2:3]([O:10][C:11]([C:13]1([C:44]([O:46]CC2C=CC=CC=2)=[O:45])[CH2:18][CH2:17][N:16]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[N:30]=[C:29]([C:31]4[CH:36]=[CH:35][C:34]([C:37]5[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=5)=[C:33]([F:43])[CH:32]=4)[O:28][N:27]=3)=[CH:22][CH:21]=2)[CH2:15][CH2:14]1)=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O1CCCC1>[CH2:3]([O:10][C:11]([C:13]1([C:44]([OH:46])=[O:45])[CH2:18][CH2:17][N:16]([CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]3[N:30]=[C:29]([C:31]4[CH:36]=[CH:35][C:34]([C:37]5[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=5)=[C:33]([F:43])[CH:32]=4)[O:28][N:27]=3)=[CH:24][CH:25]=2)[CH2:15][CH2:14]1)=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 595094331-{4-[5-(2-Fluorobiphenyl-4-yl)-1,2,4-oxadiazole-3-yl]benzyl}piperidine-4,4-dicarboxylic acid dibenzyl ester

생성물 1

HCID 595094311-{4-[5-(2-Fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4,4-dicarboxylic acid benzyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

An aqueous solution (50 mL) of sodium hydroxide (1.7 g, 0.043 mol) is added to a stirred solution of 1-{4-[5-(2-fluorobiphenyl-4-yl)-1,2,4-oxadiazole-3-yl]benzyl}piperidine-4,4-dicarboxylic acid dibenzyl ester (18.3 g, 0.027 mol) in tetrahydrofuran (150 mL). The reaction mixture is stirred overnight at room temperature and then concentrated under reduced pressure. The residue is acidified to pH ˜6 with diluted hydrochloric acid to give a solid which is filtered and washed with diethylether (100 mL) to furnish 1-{4-[5-(2-fluorobiphenyl-4-yl)-1,2,4-oxadiazole-3-yl]benzyl}piperidine-4,4-dicarboxylic acid mono benzyl ester.

후처리

  1. concentrationconcentrated under reduced pressure
  2. customto give a solid which
  3. filtrationis filtered
  4. washwashed with diethylether (100 mL)

출처 및 근거

ORD 기록
ord-c34be227dbbe445e834007c521940477
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809539B2

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