Sodium Azide → 4-(azidomethyl)tetrahydro-2H-pyran

HRID 240759

반응식

HRID 240759 반응식
I[CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[N-:9]=[N+:10]=[N-:11].[Na+]>CS(C)=O.C(OCC)C>[N:9]([CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)=[N+:10]=[N-:11]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 27955074-(Iodomethyl)oxane

생성물 1

HCID 594860844-(azidomethyl)tetrahydro-2H-pyran

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 3283Diethyl Ether용매

실험 절차

4-(Iodomethyl)tetrahydro-2H-pyran (4.76 g, 21.1 mmol) was dissolved in dimethyl sulfoxide (25 mL). Sodium azide (2.70 g, 41.5 mmol) was added and the mixture was stirred at ambient temperature overnight. The resulting slurry was diluted with diethyl ether and washed with water. The organic layer was concentrated under reduced pressure to afford the title compound. The product was used directly in subsequent reactions without characterization.

후처리

  1. washwashed with water
  2. concentrationThe organic layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-36b0761f4dae4054b34f378061eef753
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648069B2

연결된 노트

불러오는 중…