Propargyl alcohol → [3-(2-Chlorophenyl)-1,2-oxazol-5-yl]methanol

HRID 2407657노트

반응식

HRID 2407657 반응식
C(N(CC)CC)C.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](Cl)=[N:16][OH:17].[CH2:19]([OH:22])[C:20]#[CH:21]>C(OCC)C>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:21]=[C:20]([CH2:19][OH:22])[O:17][N:16]=1

참가 물질

5

반응물 3

HCID 7859Propargyl alcoholHCID 8471TriethylamineHCID 38097332-Chloro-N-hydroxy-benzamidine

생성물 1

HCID 1471845[3-(2-Chlorophenyl)-1,2-oxazol-5-yl]methanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of triethylamine (48 mL) in diethyl ether (0.5 L) was added over two hours to a 0° C. solution of the compound prepared in Example 5 (50.0 g) and propargyl alcohol (31 mL) in diethyl ether (1.2 L). The reaction was stirred at room temperature overnight, washed with water, dried over anhydrous magnesium sulfate and concentrated to obtain the title compound (50.0 g) having the following physical data.

후처리

  1. washwashed with water
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c57dba5bcf7c45099b8755f5405620f7
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809538B2

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