Hydrochloric Acid → 4-Amino-5,6-dichloropicolinic Acid
반응식
[NH2:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]([O:12]C)=[O:11])[CH:3]=1.C[Si](C)(C)[O-].[K+].Cl.C(OCC)(=O)C>O1CCCC1.O>[NH2:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]([OH:12])=[O:11])[CH:3]=1참가 물질
7
실험 절차
The compound prepared in Example 405 (2.438 g) and potassium trimethylsilanolate (2.971 g) were suspended in tetrahydrofuran (100 mL) and stirred at reflux for 4 hours. The reaction mixture was dissolved in water and added to 1 N hydrochloric acid. Ethyl acetate was added and the system stirred at room temperature. The organics were dried, magnesium sulfate and concentrated under reduced pressure to furnish the title compound (2.250 g), which was used without further purification, possessing the following physical data.
후처리
- temperatureat reflux for 4 hours
- stirringthe system stirred at room temperature
- customThe organics were dried
- concentrationmagnesium sulfate and concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-2d3e1c67be8e44c29e6804966f15762b
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08809538B2
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