Phenol → 4-Methoxy-2-phenoxynicotinonitrile

HRID 2407827노트

반응식

HRID 2407827 반응식
Cl[C:2]1[N:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[Cs+].[Cs+].[C:18]1([OH:24])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CC(N(C)C)=O.O>[CH3:11][O:10][C:6]1[C:3]([C:4]#[N:5])=[C:2]([O:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:9]=[CH:8][CH:7]=1

참가 물질

6

반응물 3

HCID 996PhenolHCID 10796Cesium carbonateHCID 14709302-Chloro-4-methoxynicotinonitrile

생성물 1

HCID 14843434-Methoxy-2-phenoxynicotinonitrile수율 70.4%

시약·촉매·용매 2

HCID 962Water용매HCID 31374Dimethylacetamide용매

반응 조건

온도
75 °C

실험 절차

A solution of 2-chloro-4-methoxynicotinonitrile (1.02 g) in dimethylacetamide (30 mL) was treated with cesium carbonate (2.96 g) followed by phenol (0.683 g) at room temperature. The mixture was heated to 75° C. overnight. The mixture was cooled to room temperature, diluted with water (100 mL) and the precipitated solids collected by filtration, to provide the title compound (0.964 g) with the following physical data.

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe precipitated solids collected by filtration

출처 및 근거

ORD 기록
ord-8d5421dd4a6348a785c1ad852bfeac4f
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809538B2

반응 노트

불러오는 중…