Methylhydrazine → HCID 86707218, 화합물
반응식
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9](=O)[CH:10]=[CH:11][N:12](C)[CH3:13])=[C:4]([F:16])[CH:3]=1.C[NH:18]N>CO>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]2[CH:10]=[CH:11][N:12]([CH3:13])[N:18]=2)=[C:4]([F:16])[CH:3]=1참가 물질
4
실험 절차
A mixture of 1-(4-bromo-2,6-difluorophenyl)-3-(dimethylamino)-2-propene-1-one (i.e. the product of Step A, 2.39 g, 8.24 mmol) and methylhydrazine (0.42 g, 9.05 mmol) in methanol (50 mL) was stirred at room temperature overnight. The reaction mixture was then concentrated under reduced pressure, and the residue was purified by medium pressure liquid chromatography on silica gel eluted with 0 to 100% ethyl acetate in hexanes to yield the title compound (0.86 g).
후처리
- concentrationThe reaction mixture was then concentrated under reduced pressure
- customthe residue was purified by medium pressure liquid chromatography on silica gel
- washeluted with 0 to 100% ethyl acetate in hexanes
출처 및 근거
- ORD 기록
- ord-97edef35f0e34ee9ba9b3fb1f5f44504
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08815772B2
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