2-Methoxy-5-nitroaniline → N-(2-methoxy-5-nitrophenyl)propanamide
반응식
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:4]=1[NH2:5].C(N(CC)CC)C.[C:20](Cl)(=[O:23])[CH2:21][CH3:22]>ClCCl>[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:4]=1[NH:5][C:20](=[O:23])[CH2:21][CH3:22]참가 물질
5
실험 절차
2-methoxy-5-nitroaniline (1) (10.1 g, 60.0 mmol) in 250 mL dichloromethane at 0°-5° C. was treated with triethylamine (10.0 g, 100.0 mmol) and propionyl chloride (6.7 g, 6.3 mL, 72.0 mmol) for 1 hour and 0.5 h at room temperature (RT). Normal aqueous workup and removal of solvent gave a light yellow solid which was washed with hexane/EtOAc (9:1) to yield solid N-(2-Methoxy-5-nitro-phenyl)-propionamide (2) (13.2 g, 98%).
후처리
- customNormal aqueous workup and removal of solvent
- customgave a light yellow solid which
- washwas washed with hexane/EtOAc (9:1)
출처 및 근거
- ORD 기록
- ord-f027d2a09ee44c4cb92ff0e7f92ae1ce
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08648104B2
반응 노트
불러오는 중…