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Methanol → HCID 178493491, 화합물

HRID 2409689
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HRID 2409689 반응식
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[CH:4][C:3]=1[C:12]1[C:21]2[N:20]=[CH:19][CH:18]=[N:17][C:16]=2[C:15]([C:22]([OH:24])=O)=[CH:14][CH:13]=1.[N+:25]([C:28]1[NH:29][CH:30]=[C:31]([CH2:33][N:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)[N:32]=1)([O-])=O.CO.C1COCC1.CO>[Ni].C(Cl)Cl.CO>[N:34]1([CH2:33][C:31]2[N:32]=[C:28]([NH:25][C:22]([C:15]3[C:16]4[N:17]=[CH:18][CH:19]=[N:20][C:21]=4[C:12]([C:3]4[CH:4]=[C:5]([O:10][CH3:11])[CH:6]=[C:7]([O:8][CH3:9])[C:2]=4[F:1])=[CH:13][CH:14]=3)=[O:24])[NH:29][CH:30]=2)[CH2:38][CH2:37][CH2:36][CH2:35]1
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참가 물질

7

반응물 4

HCID 887MethanolHCID 21899815MeOH tetrahydrofuranHCID 592928668-(2-Fluoro-3,5-dimethoxy-phenyl)quinoxaline-5-carboxylic acidHCID 1785268981H-Imidazole, 2-nitro-4-(1-pyrrolidinylmethyl)-

생성물 1

HCID 178493491HCID 178493491, 화합물

시약·촉매·용매 2

HCID 935
Nickel
촉매
HCID 21226129Dichloromethane methanol용매

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온도
65 °C

실험 절차

The title compound was prepared in analogy to the procedures described in Example 14 but stirring the reaction mixture for 6 h at 65° C. and using 8-(2-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (Step 94.1). 2-Nitro-4-pyrrolidin-1-ylmethyl-1H-imidazole (Step 19.1) instead of 2-nitroimidazole was used in Step 14.3, and Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2. The title compound: ESI-MS: 477.2 [M+H]+; tR=3.28 min (System 1); TLC: Rf=0.11 (DCM/MeOH/NH3aq, 94:5:1).

후처리

  1. customThe title compound was prepared in analogy to the procedures

출처 및 근거

ORD 기록
ord-69e74f95eae14e62997cefb24620835e
출처 데이터셋
uspto-grants-2014_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08815901B2

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