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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 241028생성일: 2026년 10월 26일

N-Cbz-d-alanine → Phenylmethyl{(1R)-1-[6-bromo-3-({[2-(trimethylsilyl)ethyl]oxy}methyl)-3H-imidazo[4,5-b]pyridin-2-yl]ethyl}({[2-(trimethylsilyl)ethyl]oxy}methyl)carbamate

https://huagongshe.com/reaction/241028

반응식

참여 물질

역할이름HCID투입량
반응물N-Cbz-d-alanineHCID 70832—
반응물5-Bromopyridine-2,3-diamineHCID 691156—
반응물2-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 2724271—
생성물Phenylmethyl{(1R)-1-[6-bromo-3-({[2-(trimethylsilyl)ethyl]oxy}methyl)-3H-imidazo[4,5-b]pyridin-2-yl]ethyl}({[2-(trimethylsilyl)ethyl]oxy}methyl)carbamateHCID 68773284—

반응 단계

Synthesized according to the method of reagent preparation 19 by using 5-bromo-2,3-diaminopyridine and N-(benzyloxycarbonyl)-D-alanine in step 1 and 2-(trimethylsilyl)ethoxymethyl chloride in step 3. MS (EI) for C28H43BrN34O4Si2: 636 (MH+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08648066B2
출처 데이터셋uspto-grants-2014_02
ORD IDord-051b6384e3ef49d690af3c5d455552cf
출처 메모uspto-grants-2014_02