Tetrahydrofuran → HCID 67183312, 화합물

HRID 2410430노트

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HRID 2410430 반응식
Cl(O)(=O)(=O)=O.CC1(C)[O:11][C@@H:10]2[O:12][C@H:13]([CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=3)[C@H:14]([CH2:15][CH2:16][N:17]3[C:25](=[O:26])[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[C:18]3=[O:27])[C@@H:9]2[O:8]1.O1CCCC1>C(#N)C.C(OCC)(=O)C.O>[OH:8][C@@H:9]1[C@H:10]([OH:11])[O:12][C@H:13]([CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:38])([F:37])[F:39])=[CH:32][CH:31]=2)[C@@H:14]1[CH2:15][CH2:16][N:17]1[C:18](=[O:27])[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:25]1=[O:26]

참가 물질

7

반응물 3

HCID 8028TetrahydrofuranHCID 24247Perchloric AcidHCID 67181417HCID 67181417, 화합물

생성물 1

HCID 67183312HCID 67183312, 화합물

시약·촉매·용매 3

HCID 962Water용매2회HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매

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온도
55 °C

실험 절차

Perchloric acid (0.2 mL) was added to a solution of the compound obtained from step e above (0.225 g) in acetonitrile (4 mL), water (1 mL), and tetrahydrofuran (0.5 mL) at room temperature. The reaction mixture was heated to 55° C. for 30 minutes. The reaction mixture was then quenched using a sodium bicarbonate solution. The solvents were evaporated at reduced pressure. The residue thus obtained was taken in ethyl acetate and water. The organic layer was separated, washed with water and brine solution, and dried over anhydrous sodium sulphate. The solvent was concentrated under reduced pressure to yield the title compound (0.22 g).

후처리

  1. customat room temperature
  2. customThe reaction mixture was then quenched
  3. customThe solvents were evaporated at reduced pressure
  4. customThe residue thus obtained
  5. customThe organic layer was separated
  6. washwashed with water and brine solution
  7. dry with materialdried over anhydrous sodium sulphate
  8. concentrationThe solvent was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-73079a81b3714cedbe94c08541c07b55
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816073B2

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