HCID 86663049, 화합물 → HCID 86663051, 화합물
반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:18]([O:20][CH3:21])=[O:19])[C:5]2[NH:6][C:7]3[CH:8]=[C:9]([N+:15]([O-])=O)[CH:10]=[CH:11][C:12]=3[C:13]=2[N:14]=1>[Ni].C1COCC1>[NH2:15][C:9]1[CH:10]=[CH:11][C:12]2[C:13]3[N:14]=[C:2]([Br:1])[CH:3]=[C:4]([C:18]([O:20][CH3:21])=[O:19])[C:5]=3[NH:6][C:7]=2[CH:8]=1참가 물질
4
실험 절차
A suspension of methyl 2-bromo-7-nitro-5H-pyrido[3,2-b]indole-4-carboxylate (1.00 g, 2.86 mmol) and Raney nickel (1.0 g, 17 mmol, 2800 nickel slurry in water) was stirred in THF (50 mL) under H2 (balloon) for 1.5 hr. This was filtered and the filter cake was washed with warn THF (100 mL). Removal of the solvent left methyl 7-amino-2-bromo-5H-pyrido[3,2-b]indole-4-carboxylate (700 mg, 2.08 mmol, 73% yield) as a solid. MS (ESI) m/z 321.94 (M+H). 1H NMR (500 MHz, DMSO-d6) δ ppm 11.27 (1H, br. s.), 7.78 (1H, d), 7.62 (1H, s), 6.79 (1H, br. s.), 6.60 (1H, d, J=8.5), 5 84 (2H, br. s.), 4.00 (3H, s).