Methanol → Methyl 6-amino-2-methylpyridine-3-carboxylate

HRID 2411164노트

반응식

HRID 2411164 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH3:11])[N:3]=1.S(=O)(=O)(O)O.[OH-].[Na+].[CH3:19]O>>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:19])=[O:7])=[C:4]([CH3:11])[N:3]=1

참가 물질

5

반응물 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 288755296-Amino-2-methylpyridine-3-carboxylic acid

생성물 1

HCID 55252884Methyl 6-amino-2-methylpyridine-3-carboxylate

실험 절차

6-Amino-2-methylnicotinic acid (1.00 g) was suspended in methanol (15 mL), concentrated sulfuric acid (0.5 mL) was added, and the mixture was stirred with heating under reflux for 18 hr. The reaction mixture was cooled, aqueous sodium hydroxide solution was added, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, and the solvent was evaporated to give the title compound (0.82 g).

후처리

  1. temperaturewith heating
  2. temperatureunder reflux for 18 hr
  3. temperatureThe reaction mixture was cooled
  4. extractionthe mixture was extracted with chloroform
  5. washThe organic layer was washed with saturated brine
  6. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-0abe182b5c4c4cc68431c8cbc27e4d99
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

반응 노트

불러오는 중…