Benzoyl chloride → 3-Benzoyl-1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one

반응식

[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[CH2:12][C:11]([CH3:14])([CH3:13])[NH:10][C:9]2=[O:15])=[CH:5][CH:4]=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:18]([N:10]1[C:11]([CH3:14])([CH3:13])[CH2:12][N:8]([CH2:7][C:6]2[CH:16]=[CH:17][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[C:9]1=[O:15])(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

반응물 2

HCID 7412Benzoyl chloride

HCID 712526731-(4-Methoxybenzyl)-4,4-dimethylimidazolidin-2-one

생성물 1

HCID 712524583-Benzoyl-1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one

실험 절차

Using 1-(4-methoxybenzyl)-4,4-dimethylimidazolidin-2-one (500 mg) described in Preparation Example 54 and benzoyl chloride (0.28 mL) and by the reaction and treatment in the same manner as in Preparation Example 55, the title compound (500 mg) was obtained.

출처 및 근거

ORD 기록: ord-053d771d665f4303b5198a9b5b988547
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08816079B2

반응 노트

불러오는 중…