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4-Methylmorpholine → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-3-methoxyphenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone

HRID 2411474
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HRID 2411474 반응식
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][C:8]=1[O:16][CH3:17].Cl.[NH:20]1[CH2:25][CH2:24][CH:23]([C:26]([C:28]2[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=2)=[O:27])[CH2:22][CH2:21]1.CN1CCOCC1.O.[Cl-].COC1N=C(OC)N=C([N+]2(C)CCOCC2)N=1>CO.O>[O:18]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([N:20]2[CH2:25][CH2:24][CH:23]([C:26](=[O:27])[C:28]3[CH:29]=[CH:30][C:31]([CH3:34])=[CH:32][CH:33]=3)[CH2:22][CH2:21]2)=[O:13])=[CH:9][C:8]=1[O:16][CH3:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 79724-MethylmorpholineHCID 27408174-(4-Methylbenzoyl)piperidine hydrochlorideHCID 231494114-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrateHCID 712525024-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-3-methoxybenzoic acid

생성물 1

HCID 71252144[4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-3-methoxyphenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone
수율 71.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

A mixture of 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-3-methoxybenzoic acid (285 mg) described in Preparation Example 21, (piperidin-4-yl) (p-tolyl)methanone hydrochloride (252 mg) and N-methylmorpholine (0.12 mL) was dissolved in a solution of methanol (3 mL) and water (2 mL), 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (349 mg) was added, and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated. The obtained residue was purified by column chromatography (chloroform:methanol) to give the title compound (344 mg).

후처리

  1. additionwas added
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. customthe solvent was evaporated
  5. customThe obtained residue was purified by column chromatography (chloroform:methanol)

출처 및 근거

ORD 기록
ord-7f7aca35291a46b789902613538b5cb0
출처 데이터셋
uspto-grants-2014_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08816079B2

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