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Methanol → 4-[(8-Cycloproply-3 4-dihydro-4,4-dimethylspiro[2H-1-benzopyran-2,1'-cyclopropane]-6-yl)ethynyl]-2-fluoro-benzeneacetic acid

HRID 24116
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HRID 24116 반응식
C[O:2][C:3](=[O:31])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:14]=[C:15]([CH:27]3[CH2:29][CH2:28]3)[C:16]3[O:23][C:20]4([CH2:22][CH2:21]4)[CH2:19][C:18]([CH3:25])([CH3:24])[C:17]=3[CH:26]=2)=[CH:7][C:6]=1[F:30].CO.[OH-].[Na+]>ClCCl>[CH:27]1([C:15]2[C:16]3[O:23][C:20]4([CH2:22][CH2:21]4)[CH2:19][C:18]([CH3:25])([CH3:24])[C:17]=3[CH:26]=[C:13]([C:12]#[C:11][C:8]3[CH:9]=[CH:10][C:5]([CH2:4][C:3]([OH:31])=[O:2])=[C:6]([F:30])[CH:7]=3)[CH:14]=2)[CH2:29][CH2:28]1
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참가 물질

5

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HCID 887Methanol2회HCID 14798Sodium HydroxideHCID 695487094-[(8-Cyclopropyl-3,4-dihydro-4,4-dimethylspiro[-2H-1-benzopyran-2,1'-cyclopropane]-6-yl)ethynyl]-2-fluoro-benzeneacetic acid methyl ester2회

생성물 1

HCID 98225114-[(8-Cycloproply-3 4-dihydro-4,4-dimethylspiro[2H-1-benzopyran-2,1'-cyclopropane]-6-yl)ethynyl]-2-fluoro-benzeneacetic acid

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

Following general procedure L and using 4-[(8-cyclopropyl-3,4-dihydro-4,4-dimethylspiro[2H-1-benzopyran-2,1′-cyclopropane]-6-yl)ethynyl]-2-fluoro-benzeneacetic acid methyl ester (Compound 49, 0.096 g, 0.23 mmol), 5 mL of methanol and 1M sodium hydroxide solution (2 mL) followed by flash column chromatography over silica gel (230-400 mesh) using 15% methanol in dichloromethane as the eluent, the title compound was obtained as a solid (0.093 g, 100%).

출처 및 근거

ORD 기록
ord-447a56faee464227aa7284f08570430c
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06855512B2

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