2-Pyrrolidone → 1-{4-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}pyrrolidin-2-one

HRID 2411676노트

반응식

HRID 2411676 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH:29]4[CH2:31][CH2:30]4)=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([S:32]([CH3:35])(=[O:34])=[O:33])[CH:9]=1>>[CH:29]1([C:25]2[CH:26]=[C:27]([CH3:28])[C:22]([N:19]3[CH2:20][CH2:21][N:16]([C:14]([C:11]4[CH:12]=[CH:13][C:8]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[CH:9][C:10]=4[S:32]([CH3:35])(=[O:34])=[O:33])=[O:15])[CH2:17][CH2:18]3)=[N:23][CH:24]=2)[CH2:30][CH2:31]1

참가 물질

3

반응물 2

HCID 120252-PyrrolidoneHCID 58484821(4-Bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

생성물 1

HCID 712520451-{4-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}pyrrolidin-2-one수율 84.6%

실험 절차

Using pyrrolidin-2-one (47 mg) and (4-bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (239 mg) described in Preparation Example 126 and by the reaction and treatment in the same manner as in Example 1, the title compound (204 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 126 and by the reaction and treatment in the same manner as in Example 1

출처 및 근거

ORD 기록
ord-59808e8bd86e48bc8d341efee507cc41
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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