Methyl iodide → 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-3,5-dimethylimidazolidine-2,4-dione

HRID 2411881노트

반응식

HRID 2411881 반응식
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]([CH3:28])[C:26](=[O:29])[NH:25][C:24]4=[O:30])=[C:19]([F:31])[CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:32]I>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]([CH3:28])[C:26](=[O:29])[N:25]([CH3:32])[C:24]4=[O:30])=[C:19]([F:31])[CH:18]=3)=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 712524521-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-5-methylimidazolidine-2,4-dione

생성물 1

HCID 712520551-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-3,5-dimethylimidazolidine-2,4-dione

실험 절차

Using 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-5-methylimidazolidine-2,4-dione (90 mg) described in Example 528 and methyl iodide (17 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (22 mg) was obtained.

출처 및 근거

ORD 기록
ord-4456186a3c864062b92ace45c92ace3c
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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