Hydrochloric Acid → HCID 20432562, 화합물

HRID 2412393

반응식

HRID 2412393 반응식
[CH:1]1([C:7]([N:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][CH2:10]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:22].[H][H]>C(O)C.[Pd]>[ClH:22].[CH:1]1([C:7]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 562738(4-Benzylpiperazin-1-yl)(cyclohexyl)methanoneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 20432562HCID 20432562, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

14.3 g (0.05 mole) of 1-cyclohexanecarbonyl-4-benzylpiperazine dissolved in 250 ml of ethanol and acidified with conc. HCl was treated with hydrogen over a palladium catalyst at 1500 psi and 100° C. The catalyst was removed by filtration and the solvent removed under reduced pressure. The residue was dissolved in isopropanol. On short standing a white crystalline precipitate appeared which was collected by filtration to give 10.0 g of 1-cyclohexanecarbonylpiperazine hydrochloride.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent removed under reduced pressure
  3. dissolutionThe residue was dissolved in isopropanol
  4. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-851606e24c71421794b1a3af844c8fae
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04492698

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