Water → 1-benzylazetidin-3-ol

HRID 241246노트

반응식

HRID 241246 반응식
Cl[CH2:2][CH:3]1[CH2:5][O:4]1.C(=O)(O)[O-].[Na+].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O>C(#N)C>[CH2:11]([N:18]1[CH2:5][CH:3]([OH:4])[CH2:2]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7504BenzylamineHCID 7835EpichlorohydrinHCID 516892Sodium Bicarbonate

생성물 1

HCID 38013451-benzylazetidin-3-ol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

reacting (±)-2-(chloromethyl)oxirane, sodium bicarbonate and benzylamine at about 0° C. to about 80° C. in acetonitrile and water to provide 1-benzyl-3-azetidinol, reacting the 1-benzyl-3-azetidinol and (2E/Z)-2-butenedioic acid at about 40° C., and isolating 1-benzyl-3-azetidinol (2E/Z)-2-butenedioate;

후처리

  1. customat about 0° C. to about 80° C.

출처 및 근거

ORD 기록
ord-580b9e4c2c3849bc8621a741f4fef465
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648196B2

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