Ethanol → 4-Chloro-2-(propan-2-yl)pent-4-enoic acid

HRID 2412463노트

반응식

HRID 2412463 반응식
[Cl:1][C:2](=[CH2:13])[CH2:3][CH:4]([CH:10]([CH3:12])[CH3:11])[C:5]([O:7]CC)=[O:6].C(O)C.[OH-].[Na+]>O>[Cl:1][C:2](=[CH2:13])[CH2:3][CH:4]([CH:10]([CH3:11])[CH3:12])[C:5]([OH:7])=[O:6]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 13370940HCID 13370940, 화합물

생성물 1

HCID 133709414-Chloro-2-(propan-2-yl)pent-4-enoic acid수율 70.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The ethyl 4-chloro-2-isopropyl-4-pentenoate (8.0 g, 0.039 mol) was refluxed for 20 hrs. in 15 ml of water and 15 ml of ethanol containing 4.8 g (0.12 mol) of sodium hydroxide. Most of the ethanol was removed on the rotary evaporator and the residue taken up in 100 ml of water. The aqueous solution was extracted with two 50 ml portions of ether, then acidified with conc. HCl. The acidified mixture was extracted twice with 100 ml of ether. The ether was washed with water, dried (MgSO4), and removed to leave 4.83 g (70% yield) of a light yellow oil.

후처리

  1. customMost of the ethanol was removed on the rotary evaporator
  2. extractionThe aqueous solution was extracted with two 50 ml portions of ether
  3. extractionThe acidified mixture was extracted twice with 100 ml of ether
  4. washThe ether was washed with water
  5. dry with materialdried (MgSO4)
  6. customremoved

출처 및 근거

ORD 기록
ord-f9a2d4deca2843888358603d67f89cf2
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04492799

반응 노트

불러오는 중…