Methanol → Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was drowned in water and extracted with ether. The extract was dried (MgSO4) and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (2A), b.p.: 40°-50° C. (14 Torr.).

1. temperaturea chilled (0°-5° C.)
2. custommost of the methanol was evaporated under reduced pressure
3. extractionextracted with ether
4. dry with materialThe extract was dried (MgSO4)
5. customthe solvent was evaporated
6. distillationThe residue was distilled

ORD 기록

ord-1f3bcff321814e5ab32196f36e7b65f5

출처 데이터셋

uspto-grants-1985_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04493728