Dimethyl Sulfoxide → Vinylbenzyl p-hydroxybenzoate

HRID 2412585

반응식

HRID 2412585 반응식
[CH:1]([CH:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:2].[OH:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([O-:18])=[O:17])=[CH:14][CH:13]=1.[Na+].CS(C)=O>O>[OH:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([O:18][CH:3]([CH:1]=[CH2:2])[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:17])=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 11768772Benzene, 1-(chloromethyl)-3(or 4)-ethenyl-HCID 16219477Sodium 4-hydroxybenzoate

생성물 1

HCID 20432038Vinylbenzyl p-hydroxybenzoate수율 92.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

71.5 g of vinylbenzyl chloride and 75.0 g of sodium p-hydroxybenzoate were added to 250 ml of dimethylsulfoxide and stirred and reacted at 40° C. for 4 days. Then 1,000 ml of water was added thereto, and the resulting mixture was extracted with 200 ml of ethyl acetate. After distilling off ethyl acetate, recrystallization of the residue from benzene-hexane mixture solvent yielded 110 g of vinylbenzyl p-hydroxybenzoate (m.p. 83°-85° C.).

후처리

  1. customreacted at 40° C. for 4 days
  2. extractionthe resulting mixture was extracted with 200 ml of ethyl acetate
  3. distillationAfter distilling off
  4. customethyl acetate, recrystallization of the residue from benzene-hexane mixture solvent

출처 및 근거

ORD 기록
ord-739e1f7ac7e646cd82e3c8d4326df2ef
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04493884

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