Hydrochloric Acid → 2-(5-Bromothiophen-2-yl)ethan-1-amine--hydrogen chloride (1/1)

HRID 2412658노트

반응식

HRID 2412658 반응식
[Br:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][NH:9]P(=O)(OCC)OCC)=[CH:4][CH:3]=1.C(OC(C)C)(C)C.[ClH:25].P(N)(=O)([O-])[O-]>>[ClH:25].[Br:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][NH2:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 211207Phosphoramidic acid, ion(2-)HCID 13740538diethyl N-[2-(5-bromothien-2-yl)-ethyl]-phosphoramidate

생성물 1

HCID 131315592-(5-Bromothiophen-2-yl)ethan-1-amine--hydrogen chloride (1/1)수율 60%

실험 절차

A solution containing 3.42 g. (0.01 mol) diethyl N-[2-(5-bromothien-2-yl)-ethyl]-phosphoramidate in 50 ml. diisopropyl ether saturated with hydrogen chloride is stirred overnight at ambient temperature. The crystals formed are filtered off and washed with diisopropyl ether. After drying, there is obtained 1.45 g. (yield: 60%, referred to the phosphoramidate used) of the desired product in the form of silverygrey flakes; m.p. 220° C. (decomposition)

후처리

  1. additionA solution containing 3.42 g
  2. customThe crystals formed
  3. filtrationare filtered off
  4. washwashed with diisopropyl ether
  5. customAfter drying
  6. customthere is obtained 1.45 g

출처 및 근거

ORD 기록
ord-27c98e0b85574fae9430a1f6c1868a03
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04493931

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