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Pyridine → HCID 15919396, 화합물

HRID 2413015
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HRID 2413015 반응식
[F:1][C:2]([F:21])([C:17]([F:20])([F:19])[F:18])[C:3]([F:16])([F:15])[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][C:8]=1[OH:14])=[O:5].N1C=CC=CC=1.C(#N)C.[C:31](Cl)(=[O:35])[C:32]([CH3:34])=[CH2:33]>O>[F:1][C:2]([F:21])([C:17]([F:18])([F:19])[F:20])[C:3]([F:16])([F:15])[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:31](=[O:35])[C:32]([CH3:34])=[CH2:33])=[CH:9][C:8]=1[OH:14])=[O:5]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 1049PyridineHCID 6342AcetonitrileHCID 13528Methacryloyl chlorideHCID 70060N-(4-Amino-2-hydroxyphenyl)-2,2,3,3,4,4,4-heptafluorobutyramide

생성물 1

HCID 15919396HCID 15919396, 화합물수율 61.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 64 g (0.2 mol) of 2-heptafluorobutanamido-5-aminophenol were added 18 g (0.22 mol) of pyridine and 500 ml of acetonitrile and mixture was cooled with stirring. To the solution was added dropwise 23 g (0.22 mol) of methacrylic chloride. After the completion of the reaction, 500 ml of water was added to the reaction solution and the crystals thus deposited were collected and recrystallized from acetonitrile to obtain 48 g of Monomer Coupler (15).

후처리

  1. temperaturewas cooled
  2. additionwas added to the reaction solution
  3. customthe crystals thus deposited were collected
  4. customrecrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-05698099a82b4ae3b17db3a42444e607
출처 데이터셋
uspto-grants-1985_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04495272

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