Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Nitropropane → 5-Bromo-3-(2-methyl-2-nitropropyl)indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Nitropropane | HCID 398 | — |
| 반응물 | Indole, 5-bromo-3-(dimethylamino)methyl- | HCID 13249 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Diisopropyl Ether | HCID 7914 | — |
| 생성물 | 5-Bromo-3-(2-methyl-2-nitropropyl)indole | HCID 12619661 | — |
반응 단계
5-Bromogramine, 60.0 g., 165 g. of 2-nitropropane, and 10.5 g. of sodium hydroxide pellets were caused to react under the conditions of Procedure 10C. The product was recovered as a dark syrup-like liquid from which the crystalline product was obtained by dissolving in i-Pr2O. The crystalline material was recrystallized from i-Pr2O to yield 48.6 g. of tan crystalline product, m.p. 106°-109°. The structure was confirmed by examination of the NMR spectrum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04495352 |
| 출처 데이터셋 | uspto-grants-1985_01 |
| ORD ID | ord-cc9d840aa0164f5180edf71ebc0b6051 |
| 출처 메모 | uspto-grants-1985_01 |