Hydrochloric Acid → SK&F 101055

HRID 2413112노트

반응식

HRID 2413112 반응식
[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9](C#N)[CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl>C(O)(=O)C>[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 13392479HCID 13392479, 화합물

생성물 1

HCID 117762SK&F 101055

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The 6-chloro-3-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine was refluxed for 19 hours in a mixture of 30 ml. of glacial acetic acid and 30 ml. of 6N hydrochloric acid. The mixture was concentrated in vacuo to yield 6-chloro-2,3,4,5-tetrahydro-1H-3-benzazepine as the hydrochloride salt of m.p. 214°-215° from ethanol. This salt in turn gave the base 6-chloro-2,3,4,5-tetrahydro-1H-3-benzazepine on treatment with dilute sodium hydroxide solution.

후처리

  1. concentrationThe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-6d0a57a318b141eebba82c106f79068b
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04496558

반응 노트

불러오는 중…