Hydrochloric Acid → 2-Methylbenzo[b]thiophene-5-carboxylic acid methyl ester

HRID 2413230노트

반응식

HRID 2413230 반응식
[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:4]=2[CH:3]=1.Cl.[CH3:15]O>>[CH3:15][O:12][C:11]([C:9]1[CH:8]=[CH:7][C:5]2[S:6][C:2]([CH3:1])=[CH:3][C:4]=2[CH:10]=1)=[O:13]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1366303686792-71-4

생성물 1

HCID 136630372-Methylbenzo[b]thiophene-5-carboxylic acid methyl ester

실험 절차

A solution of 2-methylbenzo[b]thiophene-5-carboxylic acid (17.4 g) in methanol (250 ml) was saturated with hydrogen chloride and then heated under reflux for 30 minutes. The solid which crystallised out on cooling was filtered off and dried to give 2-methylbenzo[b]thiophene-5-carboxylic acid methyl ester (16.7 g), m.p. 97°-98°.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 30 minutes
  3. customThe solid which crystallised out
  4. temperatureon cooling
  5. filtrationwas filtered off
  6. customdried

출처 및 근거

ORD 기록
ord-e8fbe33ed8f14e1f95604c716e3bde80
출처 데이터셋
uspto-grants-1985_01
특허 번호
US04496572

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