L-Tyrosine → Oxitriptan

HRID 2413524노트

반응식

N[C@H](C(O)=O)CC1C=CC([OH:10])=CC=1.[NH2:14][C@H:15]([C:26]([OH:28])=[O:27])[CH2:16][C:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[NH:19][CH:18]=1>>[OH:10][C:23]1[CH:24]=[C:25]2[C:20]([NH:19][CH:18]=[C:17]2[CH2:16][C@@H:15]([C:26]([OH:28])=[O:27])[NH2:14])=[CH:21][CH:22]=1

참가 물질

반응물 2

HCID 6057L-Tyrosine

HCID 6305L-Tryptophan

생성물 1

HCID 439280Oxitriptan

실험 절차

The process is conducted as described in the foregoing Example 6, except that instead of tyrosine 0.21 g of tryptophane is used, the reaction medium pH is 4.0. 0.105 g of 5-hydroxytryptophan is obtained (50% as calculated for the starting compound) having melting point of 287°-288° C. The composition, in percent, is as follows:

출처 및 근거

ORD 기록: ord-64ca46fd4806405892cc4bee130d7e38
출처 데이터셋: uspto-grants-1988_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04718994

반응 노트

불러오는 중…