Thiourea → 5-(2-Amino-4-thiazolyl)-1,3-dihydro-2H-indol-2-one

HRID 2414110노트

반응식

HRID 2414110 반응식
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)=O.[NH2:15][C:16]([NH2:18])=[S:17]>CCO>[NH2:18][C:16]1[S:17][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[NH:10][C:9](=[O:14])[CH2:8]3)[N:15]=1

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 220993095-(Bromoacetyl)-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 26087615-(2-Amino-4-thiazolyl)-1,3-dihydro-2H-indol-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 5-(α-bromoacetyl)oxindole (5 g) and thiourea (1.67 g) in absolute EtOH (250 ml) is refluxed for 30 minutes. The reaction mixture is cooled to RT, filtered, and washed with absolute EtOH affording the desired product. The free base is converted to its methanesulfonate salt by the procedure previously described in Example 12, affording the desired product, M.P.=244°-246° C.

후처리

  1. filtrationfiltered
  2. washwashed with absolute EtOH affording the desired product

출처 및 근거

ORD 기록
ord-3b586d910641479c91ccb9d565a2c5aa
출처 데이터셋
uspto-grants-1988_01
특허 번호
US04721721

반응 노트

불러오는 중…