2,3-Diaminopyridine → HCID 66869810, 화합물

HRID 241412

반응식

HRID 241412 반응식
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[C:4](O)=O.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([NH2:18])[C:13]=1[NH2:19].[OH-].[Na+]>O>[Br:11][C:8]1[CH:7]=[C:3]([C:4]2[NH:18][C:14]3[C:13]([N:19]=2)=[N:12][CH:17]=[CH:16][CH:15]=3)[C:2]([NH2:1])=[N:10][CH:9]=1

참가 물질

5

반응물 3

HCID 99562,3-DiaminopyridineHCID 14798Sodium HydroxideHCID 7374452-Amino-5-bromonicotinic acid

생성물 1

HCID 66869810HCID 66869810, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
160 °C

실험 절차

50 mg (0.230 mmol) I) of 2-amino-5-bromonicotinic acid and 27.6 mg (0.253 mmol) of pyridine-2,3-diamine are added to 451.5 mg (5 mmol) of polyphosphoric acid, and the mixture is stirred at 160° C. for 4 days. The reaction mixture is cooled to room temperature, water is added, and the mixture is adjusted to pH 12 by means of 1N NaOH. The precipitate formed is filtered off with suction and dried, giving 5-bromo-3-(1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-ylamine.

후처리

  1. temperatureThe reaction mixture is cooled to room temperature
  2. customThe precipitate formed
  3. filtrationis filtered off with suction
  4. customdried

출처 및 근거

ORD 기록
ord-725e8d02c86f429892222bd9e70741e6
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648201B2

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