Acetic Acid → 4-methyl-2,7-diphenyl-1H-pyrazolo[3,4-b]pyridine-3,6-dione

HRID 2414712노트

반응식

HRID 2414712 반응식
[C:1]1([N:7]2[C:11](=[O:12])[CH2:10][C:9]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20](OCC)(=[O:25])[CH2:21][C:22]([CH3:24])=O.C(O)(=O)C>O>[C:1]1([N:7]2[C:11](=[O:12])[C:10]3[C:22]([CH3:24])=[CH:21][C:20](=[O:25])[N:13]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:9]=3[NH:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 8868Ethyl AcetoacetateHCID 178516394HCID 178516394, 화합물

생성물 1

HCID 3603164-methyl-2,7-diphenyl-1H-pyrazolo[3,4-b]pyridine-3,6-dione수율 34.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-Phenyl-3-anilino-2-pyrazolin-5-one (25 g), ethyl acetoacetate (18 g) and acetic acid (150 ml) were heated to be refluxed for 6 hours. The reaction solution was diluted with water, and the resulting solid matter is crystallized from acetonitrile to obtain 10.9 g of 2,7-diphenyl-4-methylpyrazolo(3,4-b)pyridin-3,6-dione. It had a melting point of from 145 to 147° C.

후처리

  1. temperatureto be refluxed for 6 hours
  2. customthe resulting solid matter is crystallized from acetonitrile

출처 및 근거

ORD 기록
ord-138bd8c2fa4e4394a2ab02c073fd26da
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06815152B2

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