Water → 1-(4-Bromovaleroyl)-4-methylpiperidine

HRID 2414781노트

반응식

HRID 2414781 반응식
[CH3:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][CH:9]([CH3:15])[CH2:10][CH2:11][C:12](Cl)=[O:13].O>C(#N)C>[Br:8][CH:9]([CH3:15])[CH2:10][CH2:11][C:12]([N:5]1[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH2:4]1)=[O:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 693814-MethylpiperidineHCID 22643413HCID 22643413, 화합물

생성물 1

HCID 226434181-(4-Bromovaleroyl)-4-methylpiperidine수율 82%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1.09 g of 4-methylpiperidine was dissolved in 10 ml of acetonitrile and added dropwise with 1.09 g of 4-bromovaleroyl chloride. The reaction mixture was stirred for 2 hours, then poured into water and extracted with ethyl acetate. The organic layer was washed with wafer and dried over sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 1.07 g of the title compound (yield: 82%).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with wafer
  3. dry with materialdried over sodium sulfate
  4. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-be3d31fd80a34a63842c8ba79f41da24
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06815455B1

반응 노트

불러오는 중…