Hydrochloric Acid → HCID 22640723, 화합물

HRID 2415134노트

반응식

HRID 2415134 반응식
[C:1](/[C:3](=[CH:7]\[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)/[C:4]([NH2:6])=[O:5])#[N:2].Cl>C(O)C.[Pd]>[NH2:2][CH2:1][CH:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([NH2:6])=[O:5]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 725466BENZALCYANOACETAMIDE

생성물 1

HCID 22640723HCID 22640723, 화합물수율 119.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of (E)-2cyano-3-phenyl-acrylamide (0.50 g, 2.91 mmol) was dissolved in ethanol (25 mL). Concentrated HCl (1 mL) was added, followed by 10% degussa palladium on carbon (1.0 g). The mixture was subjected to hydrogenation conditions (55 psi) for 24 hours. It was filtered through Celite and concentrated to give the product (0.62 g, 100%) as a white solid. [M+H]+ 179.

후처리

  1. filtrationIt was filtered through Celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-291a905c7d0841f0a7594e8035bd4e58
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06818655B2

반응 노트

불러오는 중…