Losartan → Losartan Ang-(1-7) Arginine

HRID 241528

반응식

HRID 241528 반응식
[CH3:1][CH2:2][C@@H:3]([C@H:5]([NH:26][C:27]([C@@H:29]([NH:38][C:39]([C@@H:41]([NH:45][C:46]([C@@H:48]([NH:56][C:57]([C@@H:59]([NH2:64])[CH2:60][C:61]([OH:63])=[O:62])=[O:58])[CH2:49][CH2:50][CH2:51][N:52]=[C:53]([NH2:55])[NH2:54])=[O:47])[CH:42]([CH3:44])[CH3:43])=[O:40])[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=1)=[O:28])[C:6]([NH:8][C@H:9]([C:16]([N:18]1[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][CH2:20][CH2:19]1)=[O:17])[CH2:10][C:11]1[NH:15][CH:14]=[N:13][CH:12]=1)=[O:7])[CH3:4].[NH2:65][C@H:66]([C:74]([OH:76])=[O:75])[CH2:67][CH2:68][CH2:69][NH:70][C:71](=[NH:73])[NH2:72].[CH3:77][CH2:78][CH2:79][CH2:80][C:81]1[N:85]([CH2:86][C:87]2[CH:88]=[CH:89][C:90]([C:93]3[CH:94]=[CH:95][CH:96]=[CH:97][C:98]=3[C:99]3[N:103]=[N:102][NH:101][N:100]=3)=[CH:91][CH:92]=2)[C:84]([CH2:104][OH:105])=[C:83]([Cl:106])[N:82]=1>O>[CH3:77][CH2:78][CH2:79][CH2:80][C:81]1[N:85]([CH2:86][C:87]2[CH:92]=[CH:91][C:90]([C:93]3[CH:94]=[CH:95][CH:96]=[CH:97][C:98]=3[C:99]3[N:103]=[N:102][NH:101][N:100]=3)=[CH:89][CH:88]=2)[C:84]([CH2:104][OH:105])=[C:83]([Cl:106])[N:82]=1.[CH3:1][CH2:2][C@@H:3]([C@H:5]([NH:26][C:27]([C@@H:29]([NH:38][C:39]([C@@H:41]([NH:45][C:46]([C@@H:48]([NH:56][C:57]([C@@H:59]([NH2:64])[CH2:60][C:61]([OH:63])=[O:62])=[O:58])[CH2:49][CH2:50][CH2:51][N:52]=[C:53]([NH2:55])[NH2:54])=[O:47])[CH:42]([CH3:44])[CH3:43])=[O:40])[CH2:30][C:31]1[CH:32]=[CH:33][C:34]([OH:37])=[CH:35][CH:36]=1)=[O:28])[C:6]([NH:8][C@H:9]([C:16]([N:18]1[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][CH2:20][CH2:19]1)=[O:17])[CH2:10][C:11]1[NH:15][CH:14]=[N:13][CH:12]=1)=[O:7])[CH3:4].[NH2:65][C@H:66]([C:74]([OH:76])=[O:75])[CH2:67][CH2:68][CH2:69][NH:70][C:71](=[NH:72])[NH2:73]

참가 물질

5

반응물 3

HCID 3961LosartanHCID 123805Angiotensin-(1-7)2회HCID 178418600HCID 178418600, 화합물3회

생성물 1

HCID 178441682Losartan Ang-(1-7) Arginine

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

The Ang-(1-7) losartanate compound (PID) was weighed and placed in a beaker to which a few milliliters of Milli-Q water were added. Since this compound is insoluble in water a turbid solution was observed having suspended particles. L-arginine was added to the solution under agitation, at a molar ratio of 4:1:1 (L-arginine:Losartan:Angiotensin-(1-7)), and a total clearing of the solution was observed, which indicated the solubility of the compound after the interaction with L-arginine. The final solution was placed in eppendorf tubes and frozen in liquid nitrogen, being submitted to the lyophilization process for 24 hours. The compound was called PAD and was submitted to physicochemical characterization.

후처리

  1. additionwere added
  2. temperaturefrozen in liquid nitrogen

출처 및 근거

ORD 기록
ord-75fe930b28d34ffb8011e18951ae6050
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653031B2

연결된 노트

불러오는 중…