Triethylamine → N-Hydroxy-1-methyl-1H-imidazole-2-carboximidamide

HRID 2415755

반응식

HRID 2415755 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]#[N:8].Cl.[NH2:10][OH:11].C(N(CC)CC)C>CO>[OH:11][N:10]=[C:7]([C:3]1[N:2]([CH3:1])[CH:6]=[CH:5][N:4]=1)[NH2:8]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 109534431-Methyl-1H-imidazole-2-carbonitrile

생성물 1

HCID 136299241N-Hydroxy-1-methyl-1H-imidazole-2-carboximidamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-Methyl-2-cyanoimidazole (0.85 g, 8.0 mmol) (J. Chem. Soc. Perkin Trans. I 1994, 239) was dissolved in methanol (20 mL), then hydroxylamine hydrochloride (0.66 g, 9.6 mmol) and triethylamine (1.3 mL, 9.6 mmol) were added and the mixture was stirred at room temperature for 1 hour. The mixture was chilled in an ice-bath, then the solid was collected by filtration, washed with methanol and dried to give the title compound as a white crystalline solid which was contaminated with triethylamine hydrochloride (0.90 g).

후처리

  1. temperatureThe mixture was chilled in an ice-bath
  2. filtrationthe solid was collected by filtration
  3. washwashed with methanol
  4. customdried

출처 및 근거

ORD 기록
ord-bf5041527765454d93a2801159e0a1e3
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06821972B2

연결된 노트

불러오는 중…