Triethylamine → N'-Hydroxy-3-(methylamino)-2-pyrazinecarboximidamide
반응식
[CH3:1][NH:2][C:3]1[C:8]([C:9]#[N:10])=[N:7][CH:6]=[CH:5][N:4]=1.C(N(CC)CC)C.Cl.[NH2:19][OH:20]>CO>[OH:20][N:19]=[C:9]([C:8]1[C:3]([NH:2][CH3:1])=[N:4][CH:5]=[CH:6][N:7]=1)[NH2:10]참가 물질
5
실험 절차
To a solution of 2-methylamino-3-cyanopyrazine (J. Heterocycl. Chem. 1992, 29, 1689-92) (0.37 g, 2.8 mmol) in methanol (10 mL) was added triethylamine (0.4 mL, 2.8 mmol) followed by hydroxylamine hydrochloride (0.19 g, 2.8 mmol) and the reaction was stirred at room temperature for 4 hours. The mixture was filtered, the filtrate was then evaporated to dryness. The residue was dissolved in ethyl acetate (50 mL) and washed with water (50 mL). The organic layer was dried (MgSO4) and the solvent was removed in vacuo to give the title compound was a white solid (0.45 g).
후처리
- filtrationThe mixture was filtered
- customthe filtrate was then evaporated to dryness
- dissolutionThe residue was dissolved in ethyl acetate (50 mL)
- washwashed with water (50 mL)
- dry with materialThe organic layer was dried (MgSO4)
- customthe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-d920da5ca2c3439ea36a9f1d6e43b2c7
- 출처 데이터셋
- uspto-grants-2004_11
- 특허 번호
- US06821972B2
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