Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 8-Bromo-2-chloroquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 8-Bromo-1,2-dihydroquinolin-2-one | HCID 10933094 | — |
| 생성물 | 8-Bromo-2-chloroquinoline | HCID 10955755 | — |
반응 단계
A suspension of 2.8 g (12.49 mmol) of 8-bromo-1H-quinoline-2-one in 20 ml of phosphorus oxychloride is refluxed for 90 minutes and the reaction mixture is cooled and then added dropwise to 200 ml of water. The aqueous solution is made basic with concentrated ammonia solution, the precipitate formed is filtered off and washed with water.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06821967B2 |
| 출처 데이터셋 | uspto-grants-2004_11 |
| ORD ID | ord-5a0e0f02466448bca837c883e86815a5 |
| 출처 메모 | uspto-grants-2004_11 |