反应详情

A suspension of 2.8 g (12.49 mmol) of 8-bromo-1H-quinoline-2-one in 20 ml of phosphorus oxychloride is refluxed for 90 minutes and the reaction mixture is cooled and then added dropwise to 200 ml of water. The aqueous solution is made basic with concentrated ammonia solution, the precipitate formed is filtered off and washed with water.

1. temperatureis refluxed for 90 minutes
2. temperaturethe reaction mixture is cooled
3. customthe precipitate formed
4. filtrationis filtered off
5. washwashed with water