Lithium Bromide → 1-(4-Bromo-2-phenyl-1-cyclopenten-1-yl)benzene

HRID 2416409노트

반응식

HRID 2416409 반응식
[C:1]1([C:7]2[CH2:8][CH:9](S(Cl)(=O)=O)[CH2:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].[Br-:23]>CC(C)=O>[Br:23][CH:9]1[CH2:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:10]1

참가 물질

4

반응물 2

HCID 82050Lithium BromideHCID 223232413,4-Diphenyl-3-cyclopentene-1-sulfonyl chloride

생성물 1

HCID 223232201-(4-Bromo-2-phenyl-1-cyclopenten-1-yl)benzene수율 82.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a mixture of 3,4-diphenyl-3-cyclopentene-1-sulfonyl chloride (4 g) and 3 g of LiBr was added 70 mL of acetone. Reaction mixture was stirred under reflux for 2.5 hr. Solvent was removed under reduced pressure and the residue was extracted with 60 mL of methylene chloride. Solution was filtered and solvent was removed under reduced pressure giving 3.1 g of product as brown-yellow solid.

후처리

  1. customReaction mixture
  2. temperatureunder reflux for 2.5 hr
  3. customSolvent was removed under reduced pressure
  4. extractionthe residue was extracted with 60 mL of methylene chloride
  5. filtrationSolution was filtered
  6. customsolvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-c6ed9bea1f5c4cc9959f048566ffdb48
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06825147B2

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