Hydrochloric Acid → HCID 69733595, 화합물

HRID 2416426노트

반응식

HRID 2416426 반응식
C([O:4][C@@H:5]([CH3:32])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:15](=[O:16])[C:14]2[C:17](=[O:29])[CH:18]=[C:19]([CH3:28])[N:20]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:13]=2[N:12]([CH3:30])[C:11]1=[O:31])(=O)C.Cl.C(=O)(O)[O-].[Na+]>CO>[CH2:21]([N:20]1[C:13]2[N:12]([CH3:30])[C:11](=[O:31])[N:10]([CH2:9][CH2:8][CH2:7][CH2:6][C@@H:5]([OH:4])[CH3:32])[C:15](=[O:16])[C:14]=2[C:17](=[O:29])[CH:18]=[C:19]1[CH3:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 69732875HCID 69732875, 화합물

생성물 1

HCID 69733595HCID 69733595, 화합물수율 89%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of (S)-3-(5-acetoxyhexyl)-8-benzyl-1,7-dimethylpyrido[2,3-d]pyrimidine-2,4,5(1H,3H,8H)-trione (1.2 g, 2.7 mmol), methanol (10 ml) and 37% aqueous hydrochloric acid (2 ml) was stirred at room temperature for 18 hours. The mixture was treated with saturated aqueous sodium bicarbonate solution (20 ml). The solid was filtered, rinsed with water, and air dried to afford (S)-8-benzyl-1,7-dimethyl-3-(5-hydroxyhexyl)pyrido[2,3-d]pyrimidine-2,4,5(1H,3H,8H)-trione (850 mg, 89% yield) as a white fluffy powder. 1H NMR (300 MHz, CDCl3) δ 1.17 (d, 3H), 1.38-1.6 (m, 6H), 2.47 (s, 3H), 3.63 (s, 3H), 3.78 (m, 1H), 4.05 (t, 2H), 5.28 (s, 2H), 6.56 (s, 1H), 7.23-7.57 (m, 5H).

후처리

  1. filtrationThe solid was filtered
  2. washrinsed with water, and air
  3. customdried

출처 및 근거

ORD 기록
ord-bedec1ccbe9d46d1914d787115da6a9f
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06825180B2

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