Sodium borohydride → 3-(4-(2-Pyrazinyl)phenyl)prop-2-en-1-ol

HRID 2416565노트

반응식

HRID 2416565 반응식
[BH4-].[Na+].[N:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH:17]=[O:18])=[CH:11][CH:10]=2)[CH:4]=1>C(O)C>[N:6]1[CH:7]=[CH:8][N:3]=[CH:4][C:5]=1[C:9]1[CH:10]=[CH:11][C:12]([CH:15]=[CH:16][CH2:17][OH:18])=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 22631067(2E)-3-[4-(3-pyrazinyl)phenyl]-2-propenal

생성물 1

HCID 697135193-(4-(2-Pyrazinyl)phenyl)prop-2-en-1-ol수율 89.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium borohydride (90 mg, 2.38 mmol) was added to a suspension of (2E)-3-[4-(3-pyrazinyl)phenyl]-2-propenal (400 mg, 1.90 mmol, prepared as described in Reference Example 18) in ethanol (5 mL) maintained in a room temperature water bath. After 20 min, the reaction was quenched with water (10 mL), allowed to stir for 10 min, and then concentrated to remove the ethanol. The solids were removed by filtration, washed with water, and dried in vacuo to provide 360 mg (89%) of the title compound. MS 213 (M+H)+.

후처리

  1. customthe reaction was quenched with water (10 mL)
  2. concentrationconcentrated
  3. customto remove the ethanol
  4. customThe solids were removed by filtration
  5. washwashed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-25886b0cbfaa43a78a47da7d28b3a119
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06825172B2

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