Hydrochloric Acid → HCID 22633074, 화합물

HRID 2416652

반응식

HRID 2416652 반응식
[F:1][C:2]([F:19])([F:18])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1.[ClH:20]>C(OCC)(=O)C.CO>[ClH:20].[ClH:20].[F:19][C:2]([F:1])([F:18])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 22633053tert-Butyl 4-(3,3,3-trifluoropropyl)-1-piperazine-carboxylate

생성물 1

HCID 22633074HCID 22633074, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매3회

실험 절차

To a solution of tert-butyl 4-(3,3,3-trifluoropropyl)-1-piperazinecarboxylate (5.77 g) in ethyl acetate (13 ml) and methanol (10 ml) was added dropwise 4N hydrogen chloride in ethyl acetate (29 ml) at 0° C. The mixture was warmed to room temperature and stirred for 2 hours. The reaction mixture was diluted with ethyl acetate. The resulting precipitate was collected by filtration, washed with ethyl acetate and dried in vacuo to give the title compound (4.70 g) as a pale yellow solid.

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-2433db7004dd4e0fa52156fbfdc13bee
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06825200B1

연결된 노트

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