Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3,5-Dimethyl-1H-pyrrole-2-carbaldehyde | HCID 270465 | — |
| 반응물 | 5-(2-Oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one | HCID 66636156 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one | HCID 66636332 | — |
반응 단계
A solution of 5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one (4.3 mmoles), 3,5-dimethyl-1H-pyrrole-2-carbaldehyde (5.17 mmoles) and piperidine (3 mmoles) in ethanol (30 ml) is heated at reflux for 24 hours. The solid formed is filtered off, washed with ethanol, with water and then with ethanol and dried in vacuo to yield the title product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653073B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-aec92611ce764018841a7c927e0ad948 |
| 출처 메모 | uspto-grants-2014_02 |