Piperidine → 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one

HRID 241733ノート

反応式

HRID 241733 の反応式
[O:1]=[C:2]1[N:6]([CH2:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH2:11]3)[CH2:5][CH2:4][O:3]1.[CH3:18][C:19]1[CH:23]=[C:22]([CH3:24])[NH:21][C:20]=1[CH:25]=O.N1CCCCC1>C(O)C>[CH3:18][C:19]1[CH:23]=[C:22]([CH3:24])[NH:21][C:20]=1[CH:25]=[C:11]1[C:10]2[C:14](=[CH:15][CH:16]=[C:8]([CH2:7][N:6]3[CH2:5][CH2:4][O:3][C:2]3=[O:1])[CH:9]=2)[NH:13][C:12]1=[O:17]

参加物

5

反応物 3

HCID 8082PiperidineHCID 2704653,5-Dimethyl-1H-pyrrole-2-carbaldehydeHCID 666361565-(2-Oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one

生成物 1

HCID 666363323-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one (4.3 mmoles), 3,5-dimethyl-1H-pyrrole-2-carbaldehyde (5.17 mmoles) and piperidine (3 mmoles) in ethanol (30 ml) is heated at reflux for 24 hours. The solid formed is filtered off, washed with ethanol, with water and then with ethanol and dried in vacuo to yield the title product.

後処理

  1. temperatureat reflux for 24 hours
  2. customThe solid formed
  3. filtrationis filtered off
  4. washwashed with ethanol, with water
  5. dry with materialwith ethanol and dried in vacuo

出典と根拠

ORDレコード
ord-aec92611ce764018841a7c927e0ad948
出典データセット
uspto-grants-2014_02
特許番号
US08653073B2

反応ノート

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