Lithium hydroxide, monohydrate → 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid

HRID 2417391노트

반응식

HRID 2417391 반응식
C[O:2][C:3](=[O:40])[C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[C:15]([OH:17])[C:14]([O:18][CH3:19])=[CH:13][C:12]=2[CH:20]2[CH:29]3[CH2:30][C:31]4[C:36]([CH:28]3[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:37](=[NH:39])[NH2:38])[CH:26]=3)[NH:21]2)=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:6][CH:5]=1.O.[OH-].[Li+]>CO.O>[C:37]([C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]([C:12]1[CH:13]=[C:14]([O:18][CH3:19])[C:15]([OH:17])=[CH:16][C:11]=1[O:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:40])=[O:2])=[CH:9][CH:8]=1)[CH:29]1[CH2:30][C:31]3[C:36]([CH:28]21)=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[NH:38])[NH2:39]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 698950294-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid methyl ester

생성물 1

HCID 226332754-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

The mixture of 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid methyl ester (54 mg, 0.1 mmol) and lithium hydroxide monohydrate (21 mg, 0.5 mmol) in 2.5 mL of MeOH and 1.5 mL of H2O was stirred at room temperature overnight. The desired product 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid was purified using reverse phase HPLC. Mass spectrum 521 (M+1).

후처리

  1. customThe desired product 4-[2-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5-hydroxy-4-methoxy-phenoxy]-benzoic acid was purified

출처 및 근거

ORD 기록
ord-b06fef9a8e9e4e54b6721d44ebea1c22
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06825208B2

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