1,1'-Carbonyldiimidazole → 3-[2-(4-Nitro-phenyl)-ethyl]-oxazolidin-2-one

HRID 241746노트

반응식

HRID 241746 반응식
C1N=CN([C:6](N2C=NC=C2)=[O:7])C=1.[N+:13]([C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][NH:24][CH2:25][CH2:26][OH:27])=[CH:18][CH:17]=1)([O-:15])=[O:14]>CN(C1C=CN=CC=1)C.C(Cl)Cl>[N+:13]([C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][N:24]2[CH2:25][CH2:26][O:27][C:6]2=[O:7])=[CH:20][CH:21]=1)([O-:15])=[O:14]

참가 물질

5

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 227227442-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

생성물 1

HCID 107761683-[2-(4-Nitro-phenyl)-ethyl]-oxazolidin-2-one

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매2회

실험 절차

CDI (89 mmoles) is added to a solution of the compound obtained in Step A (44.5 mmoles) and DMAP (44.5 mmoles) in DCM (250 ml). After stirring for 4 hours at ambient temperature, the reaction mixture is diluted with 300 ml of DCM and then washed with 2M HCl solution (5×200 ml). The organic phase is dried over magnesium sulphate, filtered and evaporated to dryness to yield the title product in the form of an orange solid, which is used directly in the next Step.

후처리

  1. washwashed with 2M HCl solution (5×200 ml)
  2. dry with materialThe organic phase is dried over magnesium sulphate
  3. filtrationfiltered
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-fda4914ea9e44776990c417581b556d8
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653073B2

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