Triethylamine → HCID 69894059, 화합물

HRID 2417471노트

반응식

HRID 2417471 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:45]=[CH:44][C:12]([C:13]([N:15]2[CH2:21][C:20]3[CH:22]=[CH:23][C:24]([C:26]([OH:28])=O)=[CH:25][C:19]=3[N:18]([CH2:29][C:30]3[CH:35]=[CH:34][C:33]([O:36][CH:37]4[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]4)=[CH:32][CH:31]=3)[C:17](=[O:43])[CH2:16]2)=[O:14])=[CH:11][CH:10]=1.Cl.[CH3:47][NH:48][CH3:49].C(N(CC)CC)C>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:47][N:48]([CH3:49])[C:26]([C:24]1[CH:23]=[CH:22][C:20]2[CH2:21][N:15]([C:13](=[O:14])[C:12]3[CH:44]=[CH:45][C:9]([Cl:8])=[CH:10][CH:11]=3)[CH2:16][C:17](=[O:43])[N:18]([CH2:29][C:30]3[CH:35]=[CH:34][C:33]([O:36][CH:37]4[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]4)=[CH:32][CH:31]=3)[C:19]=2[CH:25]=1)=[O:28]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 10473Dimethylamine, hydrochlorideHCID 69892774HCID 69892774, 화합물

생성물 1

HCID 69894059HCID 69894059, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5 mg (0.008 mmol) of 4-(4-chlorobenzoyl)-2-oxo-1-[4-(4-piperidyloxy)benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-8-carboxylic acid trifluoroacetate was dissolved in 5 ml of dichloromethane. 2 mg (0.018 mmol) of dimethylamine hydrochloride, 3 mg (0.018 mmol) of 2-chloro-1,3-dimethylimidazonium chloride and 0.005 ml (0.036 mmol) of triethylamine were added to the obtained solution, and they were stirred overnight. The solvent was evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

후처리

  1. customThe solvent was evaporated
  2. customthe obtained crude product
  3. additionwas treated in the same manner as in step 3 in Example 1

출처 및 근거

ORD 기록
ord-1039280f42824d5f926a04540b143a8a
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06825191B2

반응 노트

불러오는 중…