참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | 6-fluoro-2,3-dihydro-1H-indol-2-one | HCID 3731013 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-(2-Chloroacetyl)-6-fluoroindolin-2-one | HCID 10609359 | — |
반응 단계
20 mL of DCM are added dropwise under nitrogen to aluminium chloride (31.1 mmol) at 0-5° C. 6-Fluoroindolin-2-one (5.18 mmol) and acetyl chloride (6.73 mmol) are added to the mixture. The reaction mixture is heated at 50° C. overnight. The reaction mixture is cooled to ambient temperature and then poured into an ice bath, and the suspension obtained is filtered and then washed with cold water to yield the title product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08653073B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_02 |
|---|
| ORD ID | ord-d78c29d352cb4bba84c7425fa3357d2b |
|---|
| 출처 메모 | uspto-grants-2014_02 |
|---|
