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Isopropanol → HCID 22632687, 화합물

HRID 2417516
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HRID 2417516 반응식
[Cl:1][C:2]1[CH:36]=[CH:35][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([OH:19])=[CH:18][C:12]=3[N:11]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([N:29]4[CH2:33][CH:32]=[CH:31][CH2:30]4)=[O:28])=[CH:23][CH:22]=3)[C:10](=[O:34])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[C:37]1(P(C2C=CC=CC=2)C2C=CC=CC=2)[CH:42]=CC=C[CH:38]=1.C(O)(C)C.CCOC(/N=N/C(OCC)=O)=O>C1COCC1.C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([O:19][CH:37]([CH3:42])[CH3:38])=[CH:18][C:12]=3[N:11]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([N:29]4[CH2:30][CH:31]=[CH:32][CH2:33]4)=[O:28])=[CH:23][CH:22]=3)[C:10](=[O:34])[CH2:9]2)=[O:7])=[CH:35][CH:36]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 3776IsopropanolHCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylateHCID 22632537HCID 22632537, 화합물

생성물 1

HCID 22632687HCID 22632687, 화합물

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매
HCID 8857
Ethyl Acetate
용매

실험 절차

22 mg (0.044 mmol) of 4-(4-chlorobenzoyl)-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-8-hydroxy-1,3,4,5-tetrahydrobenzo[e][1,4]-diazepin-2-on was dissolved in 5 ml of THF. 15 mg (0.05 mmol) of triphenylphosphine, 0.004 ml (0.05 mmol) of isopropyl alcohol and 25 mg (0.05 mmol) of diethylazo dicarboxylate were added to the obtained solution, and they were stirred at room temperature overnight. After the treatment with ethyl acetate as the extracting solvent, the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

후처리

  1. additionwas treated in the same manner as in step 3 in Example 1

출처 및 근거

ORD 기록
ord-9439a40c42604a058bdd26d3d295e228
출처 데이터셋
uspto-grants-2004_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06825191B2

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