Methane → Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxylate

HRID 2417794

반응식

HRID 2417794 반응식
[C:1]([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[NH2:20])[CH2:8][CH2:7]1)([O:3][CH2:4][CH3:5])=[O:2].N[C:22](N)=[O:23].C>C1(C)C=CC=CC=1>[C:1]([N:6]1[CH2:7][CH2:8][CH:9]([N:12]2[C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[NH:20][C:22]2=[O:23])[CH2:10][CH2:11]1)([O:3][CH2:4][CH3:5])=[O:2]

참가 물질

5

반응물 3

HCID 297MethaneHCID 1176UreaHCID 104609Ethyl 4-(2-amino-4-chloroanilino)piperidine-1-carboxylate

생성물 1

HCID 104610Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxylate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 24.7 g of 1-carbethoxy-4-(2-amino-4-chloroanilino)-piperidine and 7.2 g of urea was heated to 160°-180° C. for 3.5 hours. The melt was taken up in 250 ml of toluene and heated, while stirring, until everything had dissolved. The solution was clarified with active charcoal, filtered and concentrated to 50 ml. The product was precipitated with diisopropyl ether. Melting point: 160° C.

후처리

  1. temperaturewas heated to 160°-180° C. for 3.5 hours
  2. temperatureheated
  3. dissolutionhad dissolved
  4. filtrationfiltered
  5. concentrationconcentrated to 50 ml
  6. customThe product was precipitated with diisopropyl ether

출처 및 근거

ORD 기록
ord-ce47b2e418934eda94a0f219f6f3ac23
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04470989

연결된 노트

불러오는 중…